Shruti Bhat PhD, MBA, Lean Six Sigma Black Belt
  • Home
  • About Shruti
  • Consulting
  • Workshops
  • Patents
  • Articles
    • Case Studies
    • Innovation Portfolio Development & Patents
    • Drugs-in-the- making
    • Culture Change & Business Transformation
    • Operational Excellence, Quality & Continuous Improvement
  • Books
  • Digital
  • Blog
  • Videos
  • Contact

PK- PD considerations in design of targeted drug delivery systems

5/18/2009

0 Comments

 
Targeted drug delivery systems are designed to maximize therapeutic response by delivering drug selectively to its pharmacological site(s).  There are several factors that determine the availability of drug at the target site.  These include the rate of (a) input of targeted drug into the body plasma, (b) distribution of targeted drug to the active site, (c) release of active drug from the targeted drug at the site of action,  (d) removal (elimination) of targeted drug and free drug from the target site, (e) diffusion or transport of targeted drug and free drug from the active site to non-target sites, and (f) blood and lymph flow to and from the target site.  

APPROACHES TO TARGETED DRUG DELIVERY SYSTEM:

A)  Pro-drug :

A prodrug is pharmacologically inert form of an active drug that must undergo transformation to the parent compound in vivo by either chemical or an enzymatic reaction to exert its therapeutic effects.

B) Drug Carrier Delivery System:

Drug-carrier delivery systems employ biologically inert macromolecules to direct a drug to its target site in the body.  

​These are divided into two types:  Particulate and soluble macromolecular.  Depending on the carrier system, the drug can either be molecularly entrapped within the carrier matrix or covalently linked to the carrier molecules.  

​The major advantage of drug-carrier delivery systems is that the distribution of drug in the body depends on the physiochemical properties of the carrier not those or by alterations in the physiochemical properties of the carrier.  There are however several other factors that must be considered in the pharmaceutical development and clinical use of both soluble macromolecular and particulate bio-technical and synthetic site-specific systems.
Follow Shruti on Twitter, Facebook, YouTube, LinkedIn
0 Comments

Your comment will be posted after it is approved.


Leave a Reply.

    Shruti Bhat, global leader in business turnaround, operational excellence and continuous improvement

    New Book Released!

    top ten strategic decision-making tools for operational excellence

    Shruti's YouTube Channel ...

    Picture

    Blog Categories

    All
    3D Printing
    5S
    Agile
    Artificial Intelligence
    Automation
    Balanced Score Card
    Biotechnology
    Books
    Business Turnaround
    Case Studies
    Change Management
    Chemical Industry
    CMMI
    Continuous Improvement
    Design Thinking
    Digitalization
    Drug Delivery
    External News Links
    Food Industry
    Hall Of Fame
    Healthcare
    Hoshin Kanri
    HR Development
    Innovation
    ISO
    Just In Time
    Kaizen
    Leadership
    LEAN
    Lean Six Sigma
    Life Sciences
    Machine Learning
    Manufacturing
    Medical Devices
    Mistake Proofing
    Motivational Cards
    Nanotechnology
    Operations
    Packaging
    Patents
    Personal Products
    Process Improvement
    Product Development
    Productivity Increase
    QbD
    Quality Management
    Robotics
    Scrum
    Service Industry
    Six Sigma
    Strategy
    Supply Chain Logistics
    Telecom Industry
    TQM
    Videos
    Voice Of Customer
    Workshops

    Shruti's books...

    Picture
    shruti bhat, business process management, continuous improvement
    kaizen for pharmaceutcials, medical devices and biotech industry book by Dr Shruti Bhat
    Book on Continuous improvement tools by Dr Shruti Bhat
    kaizen for leaders, continuous process improvement tool to increase profit and organizational excellence by shruti bhat
    kaizen, shruti bhat, continuous improvement, quality, operations management
    Picture
    how to overcome challenges of creating effective teams
    how to lead a successful business transformation

    ​Micro-Learning
    ​Partner

    Picture

    Publishing Partner

    fast read books, business management books, health and wellness books, spiritual guidance books, best online book store

    Wellness
    ​Partner

    Picture
© Copyright 1992- 2022 Dr. Shruti Bhat ALL RIGHTS RESERVED.
See Terms and Conditions for details on this site usage.
SHRUTI BHAT, CONTACT
Click to connect.
Created by Macro2Micro Media