Dr.Shruti Bhat, an Expert in Pharmaceutical industry, brings to you some highlights from current pharma and clinical research news, views and data.
It’s the title of a very insightful analytical paper by Bernard Munos (Nature Reviews, Dec-2009). He applied statistical analysis techniques to the aggregate inputs and outputs of the pharmaceutical industry.
The most stunning insights from his analysis are:
1. Average annual output of the industry is constant and has been so for 60 years, despite consistent increase in R&D investment ($50 billion/year). Practically, it means that the output of the industry is not depressed, as commonly thought, but simply reflects the innovative capacity of the established R&D model. In this light,new approaches, such as the open innovation paradigm, public-private partnerships and industry consortia hold a lot of promise.
2. If the NME (New Molecular Entity) output is constant, the only way to grow is to increase the number of companies, which goes contrary to the 2009 wave of large mergers & acquisitions (M&As). However, Bernard Munos’ analysis shows that, broadly speaking, the impact of M&A in the pharmaceutical industry on R&D is “1+1=1″, which is consistent with other analysis (Grabowski, Kyle in “The Economics of Corporate Governance and Mergers”, p.262-287, 2008). A more nuanced view reveals that for small companies nearly 80% of acquisitions increased the NME output while for large companies the proportions were roughly reversed: 70% of acquisitions reduced NME output whereas 30% of acquisitions increased NME output.
3. Let’s forget the rate of innovation and focus on sales instead. After all, customer knowledge, efficient sales infrastructure and disease expertise are the core competencies of major industry players. Every commercial decision and development step that can be codified and turned into a predictable process already has been done. However, sales forecasts for new products are inaccurate nearly 80% of the time and portfolio management techniques have failed to protect the industry from patent cliffs. Munos’ analysis shows that the probability that an NME will achieve blockbuster status is about 21%, a success rate that has not changed in 20 years.
Solution? Bernard Munos’ recommendations point to the need to rethink process and culture. Quoting CEO of GSK, Jean-Pierre Garnier: “The leaders of major corporations have incorrectly assumed that R&D was scalable, could be industrialized and could be driven by detailed metrics and automation. The grand result: a loss of personal accountability, transparency and the passion of scientists in discovery and development.”
Igniting passion for discovery is a tricky task for a large corporation. However, I am confident the veritable fireworks of passion for medical discovery will very soon be a realty if research breakthroughs and promise of NME R&D successes have to be recorded often.
How do we bring in passion for discovery? Is it through good HR practises? Certainly not... and it doesn’t need management to pump in dollars either !
The answers are available for those interested to bring in a wave of change to their R&D’s systems, functioning and culture....
Reference- http://www.pharm-education.com/2010/03/what-is-future-of-medicine-what-are.html
For detailed FREE white paper on this topic, register at www.drshrutibhat.com
Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.
It’s the title of a very insightful analytical paper by Bernard Munos (Nature Reviews, Dec-2009). He applied statistical analysis techniques to the aggregate inputs and outputs of the pharmaceutical industry.
The most stunning insights from his analysis are:
1. Average annual output of the industry is constant and has been so for 60 years, despite consistent increase in R&D investment ($50 billion/year). Practically, it means that the output of the industry is not depressed, as commonly thought, but simply reflects the innovative capacity of the established R&D model. In this light,new approaches, such as the open innovation paradigm, public-private partnerships and industry consortia hold a lot of promise.
2. If the NME (New Molecular Entity) output is constant, the only way to grow is to increase the number of companies, which goes contrary to the 2009 wave of large mergers & acquisitions (M&As). However, Bernard Munos’ analysis shows that, broadly speaking, the impact of M&A in the pharmaceutical industry on R&D is “1+1=1″, which is consistent with other analysis (Grabowski, Kyle in “The Economics of Corporate Governance and Mergers”, p.262-287, 2008). A more nuanced view reveals that for small companies nearly 80% of acquisitions increased the NME output while for large companies the proportions were roughly reversed: 70% of acquisitions reduced NME output whereas 30% of acquisitions increased NME output.
3. Let’s forget the rate of innovation and focus on sales instead. After all, customer knowledge, efficient sales infrastructure and disease expertise are the core competencies of major industry players. Every commercial decision and development step that can be codified and turned into a predictable process already has been done. However, sales forecasts for new products are inaccurate nearly 80% of the time and portfolio management techniques have failed to protect the industry from patent cliffs. Munos’ analysis shows that the probability that an NME will achieve blockbuster status is about 21%, a success rate that has not changed in 20 years.
Solution? Bernard Munos’ recommendations point to the need to rethink process and culture. Quoting CEO of GSK, Jean-Pierre Garnier: “The leaders of major corporations have incorrectly assumed that R&D was scalable, could be industrialized and could be driven by detailed metrics and automation. The grand result: a loss of personal accountability, transparency and the passion of scientists in discovery and development.”
Igniting passion for discovery is a tricky task for a large corporation. However, I am confident the veritable fireworks of passion for medical discovery will very soon be a realty if research breakthroughs and promise of NME R&D successes have to be recorded often.
How do we bring in passion for discovery? Is it through good HR practises? Certainly not... and it doesn’t need management to pump in dollars either !
The answers are available for those interested to bring in a wave of change to their R&D’s systems, functioning and culture....
Reference- http://www.pharm-education.com/2010/03/what-is-future-of-medicine-what-are.html
For detailed FREE white paper on this topic, register at www.drshrutibhat.com
Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.
