Results From First Progeria Drug Trial Expected Soon.
The Pittsburgh Tribune-Review reported that only 16 "children in the United States" are currently battling progeria, but the majority of those "kids live only to age 13; almost all die from heart attacks or strokes." In 2003, the "National Institutes of Health announced" that a "gene that causes progeria" had been identified, a discovery that led to the "first progeria drug trial." Started in 2007, the study, which "involves 28 children, ages three to 18, from 16 countries," concluded in December, with investigators now ready to reveal findings regarding FTI, a drug that was "initially intended to treat cancer." Meanwhile, researchers are also conducting a "triple-drug trial" that focuses on "two a dditional drugs" -- pravastatin and zoledronate.
Brain Cancer Vaccine May Benefit Patients Who Are Not Newly Diagnosed.
The Cleveland Plain Dealer reported on a brain cancer "vaccine was designed by Dr. Andrew Parsa, principal investigator of the Brain Tumor Research Center at the University of California, San Francisco." Should research on the vaccine prove "successful, patients could conceivably control the disease and prevent a recurrence with regular vaccine booster shots." According to the Plain Dealer, "What makes this vaccine different from other vaccines developed for brain-tumor patients is that this is one of the few immune therapies designed specifically for patients who are not newly diagnosed."
FDA Warns Companies Against Claiming Dietary Supplements Can Prevent, Treat H1N1.
The Food and Drug Administration is warning four companies, including two in Florida, to stop marketing dietary supplements they claimed can prevent or treat the...swine flu virus, as officials said the products are not drugs approved for that use. The products, "being sold online," include "creams, hand sanitizers and pills." One company is even "marketing a 'miracle mineral supplement' it claimed could treat malaria, colds, flu and pneumonia; and several dietary products" said to "prevent cancer or 'attack cancer cells.'"
FDA Says Highest Available Dose Of Zocor May Cause Muscle Damage.
The FDA "said Friday the highest available dose of Zocor [simvastatin]...can cause muscle damage as well as severe and potentially lethal kidney damage”, in a statement, said, "Although muscle injury ... is a known side effect with all statins, the warning highlights the greater risk of developing muscle injury, including rhabdomyolysis, for patients when they are prescribed and use higher doses of this drug."
The "Booster Shots" blog reported that "the risk is highest in patients of Chinese descent and is also high when Zocor...is combined with certain other medications, including amiodarone, niacin, and diltiazem." One study "comparing 6,031 patients taking 80 mg daily with 6,033 patients taking 20 mg. found 52 cases of myopathy in the 80-mg group and only one in the 20-mg group."
That study also found that "11 patients taking the 80 mg dose developed rhabdomyolysis, the most serious form of myopathy which can lead to kidney failure and death, where as none of those on the 20mg dose developed the condition".