Injectable and dermatology spheres have successfully employed Nano technology to product development. Yet, there is still a wide gap in wound- healing dermatology.
The wound healing process consists of four highly integrated and over lapping phases- hemostasis, inflammation, proliferation and time remodelling. For a wound to heal successfully, all four phases of this process must occur in the proper sequence, at a specific time and continue for specific duration at optimal intensity.
Conventional wound- healing products, in majority of instances, do tend to leave scar behind. This is the case both with pharmaceutical and natural products.
For example Curcumin derived from spice turmeric, has traditionally been known to be excellent with wound healing even when administered in the raw powder form. For a formulator, the challenge is water- insoluble nature of turmeric as well as the staining property of curcumin.
Applying Nano technology to formulation development of turmeric products, is expected to circumvent the difficulties inherent in curcumin administration, enabling delivery of this therapeutic substance. Furthermore, curcumin in a Nano vesicle will assist clear infection as well as accelerate wound healing by sitting more evenly on the wound bed.
Research findings have shown that the growth of tissue and extent of scar formation can be controlled by modulating the stress at a wound site. And Nano technology shows promise for delivering many advanced wound- healing agents.
With Nano technology, you can have multiple therapeutic agents in one platform that can work synergistically in wound therapy. For example, combining turmeric with a collagen regenerating/ remodelling ingredient will further augment the healing process, wound repair and tissue regeneration and bring- on scar less wound healing.
However, the key to using Nano technology correctly to pharmaceuticals and natural products is having a complete understanding of - Which Nano materials can accelerate wound- healing, how and when to use them and which wound healing agents to incorporate viz. immunomodulatory, anti-microbials anti-inflammatory etc.
Nano technology is indeed a “magic bullet’ in developing safe, effective and targeted science based products.
About the author:
Shruti Bhat PhD MBA Certified Lean Six Sigma Black Belt is Pharmaceutical R&D and Continuous Improvement Director, Innoworks Canada
Shruti leads path-breaking product development programs such as Complex Generics, Nanotechnology and Targeted delivery systems for pharmaceuticals and natural products. Her mantra is to "Shorten development timelines, build quality-by-design, lean processes and bring products fast- to- market". Shruti integrates her proficiency in Design Thinking, Lean, Kaizen and other Continuous Improvement methodologies to improve R&D processes, productivity and profitability.
Shruti is Product Development & Continuous Improvement Advisor to several start ups, mid-size and growing firms in Canada, USA, India, Africa and other Emerging markets. Shruti has authored six books and is an invited speaker at several conferences and workshops.
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